Construct · 1 fields · 1 citations

caretaker gene: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Oncology

a tumor suppressor gene whose loss promotes cancer indirectly by weakening DNA maintenance and raising the mutation rate, rather than by directly controlling cell growth.

In oncology, caretaker gene refers to a tumor suppressor gene whose loss promotes cancer indirectly by weakening DNA maintenance and raising the mutation rate, rather than by directly controlling cell growth. This meaning comes from Kinzler (1997) in Nature.[1]

Unit
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Nearby constructs

gatekeeping4 fields · 4 citationsjingle · one word, four constructs cell2 fields · 3 citationsjingle · one word, two constructs growth4 fields · 4 citationsjingle · one word, four constructs

References

Kinzler, K. W., & Vogelstein, B. (1997). Gatekeepers and caretakers. Nature, 386(6627), 761-763. https://doi.org/10.1038/386761a0

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