Construct · 1 fields · 1 citations

Cas9 nickase: a standalone construct

One name. One construct. A landmark on the map.

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Genome editing

Cas9 variant cutting only one DNA strand, so two guides are needed for a break and specificity rises.

In genome editing, Cas9 nickase refers to cas9 variant cutting only one DNA strand, so two guides are needed for a break and specificity rises. This meaning comes from Ran (2013) in Cell.[1]

Unit
Recovery means
Measured by

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Nearby constructs

break2 fields · 4 citationsjingle · one word, two constructs cell2 fields · 3 citationsjingle · one word, two constructs editing1 fields · 2 citationsanchor · a standalone construct

References

Ran, F. A., Hsu, P. D., Lin, C., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S., Zhang, Y., & Zhang, F. (2013). Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell, 154(6), 1380-1389. https://doi.org/10.1016/j.cell.2013.08.021

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