Construct · 1 fields · 1 citations

catalytically dead Cas9: a standalone construct

One name. One construct. A landmark on the map.

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Biotechnology

a Cas9 variant that binds its target without cutting, used to block or recruit transcription machinery.

In biotechnology, catalytically dead Cas9 refers to a Cas9 variant that binds its target without cutting, used to block or recruit transcription machinery. This meaning comes from Qi (2013) in Cell.[1]

Unit
Recovery means
Measured by

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Nearby constructs

CRISPR interference1 fields · 1 citationsanchor · a standalone construct block3 fields · 6 citationsjingle · one word, three constructs cell2 fields · 3 citationsjingle · one word, two constructs

References

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013). Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression. Cell, 152(5), 1173-1183. https://doi.org/10.1016/j.cell.2013.02.022

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