Construct · 1 fields · 1 citations

CNS multiparameter optimization: a standalone construct

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Medicinal chemistry

desirability score built from six physicochemical properties that ranks how well a compound aligns with the profile of brain-penetrant drugs.

In medicinal chemistry, CNS multiparameter optimization refers to desirability score built from six physicochemical properties that ranks how well a compound aligns with the profile of brain-penetrant drugs. This meaning comes from Wager (2010) in ACS Chemical Neuroscience.[1]

Unit
Recovery means
Measured by

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Nearby constructs

compound3 fields · 3 citationsjingle · one word, three constructs profile2 fields · 2 citationsjingle · one word, two constructs score2 fields · 3 citationsjingle · one word, two constructs

References

Wager, T. T., Hou, X., Verhoest, P. R., & Villalobos, A. (2010). Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties. ACS Chemical Neuroscience, 1(6), 435-449. https://doi.org/10.1021/cn100008c

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