Construct · 1 fields · 1 citations

Comprehensive in vitro Proarrhythmia Assay: a standalone construct

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Comprehensive in vitroProarrhythmia Assay1 CONSTRUCTComprehensive in vitroSAGER · PHARMACOLOGY

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Pharmacology

a paradigm for judging a drug's risk of torsade de pointes from effects on several cardiac ion channels in silico and in human cardiomyocytes, rather than from QT prolongation alone.

In pharmacology, Comprehensive in vitro Proarrhythmia Assay refers to a paradigm for judging a drug's risk of torsade de pointes from effects on several cardiac ion channels in silico and in human cardiomyocytes, rather than from QT prolongation alone. This meaning comes from Sager (2014) in American Heart Journal.[1]

Unit
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Nearby constructs

assay1 fields · 1 citationsanchor · a standalone constructdrug-induced QT prolongation1 fields · 1 citationsanchor · a standalone constructparadigm3 fields · 4 citationsjingle · one word, three constructs

References

  1. Sager, P. T., Gintant, G., Turner, J. R., Pettit, S., & Stockbridge, N. (2014). Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium. American Heart Journal, 167(3), 292-300. https://doi.org/10.1016/j.ahj.2013.11.004

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