Construct · 1 fields · 1 citations

continuum model of tumor suppression: a standalone construct

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Oncology

the proposal that tumor suppressor dosage acts on a graded continuum, so subtle reductions in gene function, not only complete loss, can promote cancer.

In oncology, continuum model of tumor suppression refers to the proposal that tumor suppressor dosage acts on a graded continuum, so subtle reductions in gene function, not only complete loss, can promote cancer. This meaning comes from Berger (2011) in Nature.[1]

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function5 fields · 6 citationsjingle · one word, five constructs loss2 fields · 3 citationsjingle · one word, two constructs model3 fields · 3 citationsjingle · one word, three constructs

References

Berger, A. H., Knudson, A. G., & Pandolfi, P. P. (2011). A continuum model for tumour suppression. Nature, 476(7359), 163-169. https://doi.org/10.1038/nature10275

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