Construct · 1 fields · 1 citations

CpG hypermutability: a standalone construct

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Human genetics

the elevated rate of C to T change at methylated CpG sites, caused by deamination of 5-methylcytosine, which makes these sites mutation hotspots.

In human genetics, CpG hypermutability refers to the elevated rate of C to T change at methylated CpG sites, caused by deamination of 5-methylcytosine, which makes these sites mutation hotspots. This meaning comes from Coulondre (1978) in Nature.[1]

Unit
Recovery means
Measured by

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Nearby constructs

mutation4 fields · 4 citationsjingle · one word, four constructs

References

Coulondre, C., Miller, J. H., Farabaugh, P. J., & Gilbert, W. (1978). Molecular basis of base substitution hotspots in Escherichia coli. Nature, 274(5673), 775-780. https://doi.org/10.1038/274775a0

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