Construct · 1 fields · 1 citations

danger model: a standalone construct

One name. One construct. A landmark on the map.

● anchor · one construct, one field Nearest construct by meaning·not indexed
dangermodel1 CONSTRUCTDanger modelMATZINGER · 1994

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Immunology

The immune system reacts to damage, not just foreignness

In immunology, the danger model holds that the immune system is driven to respond not by whether something is foreign but by signals of tissue damage or stress, so that harmless foreign material may be tolerated while damaged self provokes a reaction. Matzinger's 1994 Tolerance, danger, and the extended family proposed that alarm signals released by injured or dying cells, rather than non-self recognition alone, decide when an immune response is launched. The referent is this account of immune activation keyed to danger signals, offered as an alternative to the strict self versus non-self view.[1]

Unit
The presence and strength of damage or alarm signals that trigger an immune response
Recovery means
Not applicable
Measured by
Supported by responses that track tissue-damage and alarm signals rather than foreignness, and by tolerance to non-self in their absence

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Nearby constructs

activation4 fields · 4 citationsjingle · one word, four constructsfamily3 fields · 3 citationsjingle · one word, three constructsmodel3 fields · 3 citationsjingle · one word, three constructs

References

  1. Matzinger, P. (1994). Tolerance, danger, and the extended family. Annual Review of Immunology, 12, 991–1045. https://doi.org/10.1146/annurev.iy.12.040194.005015

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