Construct · 1 fields · 1 citations

del Castillo-Katz mechanism: a standalone construct

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del Castillo-Katzmechanism1 CONSTRUCTDel Castillo-KatzCASTILLO · PHARMACOLOGY

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Pharmacology

two-step scheme in which agonist binding to a receptor is followed by a separate isomerization to the active state, separating affinity from efficacy.

In pharmacology, del Castillo-Katz mechanism refers to two-step scheme in which agonist binding to a receptor is followed by a separate isomerization to the active state, separating affinity from efficacy. This meaning comes from Castillo (1957) in Proceedings of the Royal Society of London. Series B - Biological Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

affinity3 fields · 4 citationsjingle · one word, three constructsagonist1 fields · 3 citationsanchor · a standalone constructbinding4 fields · 4 citationsjingle · one word, four constructs

References

  1. Castillo, J. D., & Katz, B. (1957). Interaction at end-plate receptors between different choline derivatives. Proceedings of the Royal Society of London. Series B - Biological Sciences, 146(924), 369-381. https://doi.org/10.1098/rspb.1957.0018

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