Construct · 1 fields · 1 citations

deleterious passenger hypothesis: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
deleteriouspassenger hypothesis1 CONSTRUCTDeleterious passengerMCFARLAND · ONCOLOGY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Oncology

the proposal that mildly harmful passenger mutations accumulate in tumors and slow cancer progression, opposing the effect of driver mutations.

In oncology, deleterious passenger hypothesis refers to the proposal that mildly harmful passenger mutations accumulate in tumors and slow cancer progression, opposing the effect of driver mutations. This meaning comes from McFarland (2013) in Proceedings of the National Academy of Sciences.[1]

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Nearby constructs

driver2 fields · 2 citationsjingle · one word, two constructshypothesis2 fields · 2 citationsjingle · one word, two constructsprogression3 fields · 6 citationsjingle · one word, three constructs

References

  1. McFarland, C. D., Korolev, K. S., Kryukov, G. V., Sunyaev, S. R., & Mirny, L. A. (2013). Impact of deleterious passenger mutations on cancer progression. Proceedings of the National Academy of Sciences, 110(8), 2910-2915. https://doi.org/10.1073/pnas.1213968110

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