Construct · 1 fields · 1 citations

direct neuronal reprogramming: a standalone construct

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Stem cell biology

turning non-neural cells such as fibroblasts straight into functional neurons with defined transcription factors, without a stem cell stage.

In stem cell biology, direct neuronal reprogramming refers to turning non-neural cells such as fibroblasts straight into functional neurons with defined transcription factors, without a stem cell stage. This meaning comes from Vierbuchen (2010) in Nature.[1]

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs stage2 fields · 4 citationsjingle · one word, two constructs stem2 fields · 2 citationsjingle · one word, two constructs

References

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010). Direct conversion of fibroblasts to functional neurons by defined factors. Nature, 463(7284), 1035-1041. https://doi.org/10.1038/nature08797

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