Construct · 1 fields · 1 citations

directed evolution: a standalone construct

One name. One construct. A landmark on the map.

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Protein engineering

improving a protein by repeated rounds of random mutation and selection for the property wanted.

In protein engineering, directed evolution refers to improving a protein by repeated rounds of random mutation and selection for the property wanted. This meaning comes from Chen (1993) in Proceedings of the National Academy of Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

mutation4 fields · 4 citationsjingle · one word, four constructs property4 fields · 4 citationsjingle · one word, four constructs selection4 fields · 5 citationsjingle · one word, four constructs

References

Chen, K., & Arnold, F. H. (1993). Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences, 90(12), 5618-5622. https://doi.org/10.1073/pnas.90.12.5618

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