Construct · 1 fields · 1 citations

double mutant cycle: a standalone construct

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Biochemistry

thermodynamic cycle comparing single and double mutants to measure the coupling energy between two residues in a protein or complex.

In biochemistry, double mutant cycle refers to thermodynamic cycle comparing single and double mutants to measure the coupling energy between two residues in a protein or complex. This meaning comes from Horovitz (1996) in Folding and Design.[1]

Unit
Recovery means
Measured by

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Nearby constructs

complex4 fields · 4 citationsjingle · one word, four constructs coupling4 fields · 4 citationsjingle · one word, four constructs cycle4 fields · 4 citationsjingle · one word, four constructs

References

Horovitz, A. (1996). Double-mutant cycles: a powerful tool for analyzing protein structure and function. Folding and Design, 1(6), R121-R126. https://doi.org/10.1016/s1359-0278(96)00056-9

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