Construct · 1 fields · 1 citations

drug-target residence time: a standalone construct

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Pharmacology

how long a drug stays bound to its target, argued to predict in vivo effect better than binding affinity.

In pharmacology, drug-target residence time refers to how long a drug stays bound to its target, argued to predict in vivo effect better than binding affinity. This meaning comes from Copeland (2006) in Nature Reviews Drug Discovery.[1]

Unit
Recovery means
Measured by

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Nearby constructs

affinity3 fields · 4 citationsjingle · one word, three constructs binding4 fields · 4 citationsjingle · one word, four constructs residence time3 fields · 3 citationsinvariant · one construct, three systems

References

Copeland, R. A., Pompliano, D. L., & Meek, T. D. (2006). Drug–target residence time and its implications for lead optimization. Nature Reviews Drug Discovery, 5(9), 730-739. https://doi.org/10.1038/nrd2082

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