Construct · 1 fields · 1 citations

enhancer hijacking: a standalone construct

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enhancerhijacking1 CONSTRUCTEnhancer hijackingNORTHCOTT · GENOMICS

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Genomics

activation of a gene when a structural change places it under the control of an enhancer that normally acts on another gene, a cause of cancer and disease.

In genomics, enhancer hijacking refers to activation of a gene when a structural change places it under the control of an enhancer that normally acts on another gene, a cause of cancer and disease. This meaning comes from Northcott (2014) in Nature.[1]

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Nearby constructs

activation4 fields · 4 citationsjingle · one word, four constructscause3 fields · 7 citationsjingle · one word, three constructscontrol4 fields · 5 citationsjingle · one word, four constructs

References

  1. Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., Jones, D. T. W., Kool, M., Remke, M., Cavalli, F. M. G., Zuyderduyn, S., Bader, G. D., VandenBerg, S., Esparza, L. A., Ryzhova, M., Wang, W., Wittmann, A., Stark, S., Sieber, L., Seker-Cin, H., Linke, L., Kratochwil, F., Jäger, N., Buchhalter, I., Imbusch, C. D., Zipprich, G., Raeder, B., Schmidt, S., Diessl, N., Wolf, S., Wiemann, S., Brors, B., Lawerenz, C., Eils, J., Warnatz, H., Risch, T., Yaspo, M., Weber, U. D., Bartholomae, C. C., von Kalle, C., Turányi, E., Hauser, P., Sanden, E., Darabi, A., Siesjö, P., Sterba, J., Zitterbart, K., Sumerauer, D., van Sluis, P., Versteeg, R., Volckmann, R., Koster, J., Schuhmann, M. U., Ebinger, M., Grimes, H. L., Robinson, G. W., Gajjar, A., Mynarek, M., von Hoff, K., Rutkowski, S., Pietsch, T., Scheurlen, W., Felsberg, J., Reifenberger, G., Kulozik, A. E., von Deimling, A., Witt, O., Eils, R., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Korbel, J. O., Wechsler-Reya, R. J., & Pfister, S. M. (2014). Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature, 511(7510), 428-434. https://doi.org/10.1038/nature13379

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