Construct · 1 fields · 1 citations

evolutionary double bind: a standalone construct

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Oncology

a combination strategy in which resistance to one therapy makes cancer cells more vulnerable to a second, so that adaptation to either is penalized.

In oncology, evolutionary double bind refers to a combination strategy in which resistance to one therapy makes cancer cells more vulnerable to a second, so that adaptation to either is penalized. This meaning comes from Basanta (2011) in Nature Precedings.[1]

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Nearby constructs

adaptation5 fields · 7 citationsjingle · one word, five constructs combination1 fields · 2 citationsanchor · a standalone construct resistance4 fields · 7 citationsjingle · one word, four constructs

References

Basanta, D., Basanta, D., Gatenby, R., & Anderson, A. (2011). Exploiting evolution to treat drug resistance: Combination therapy and the double bind. Nature Precedings. https://doi.org/10.1038/npre.2011.6380

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