Construct · 1 fields · 1 citations

extended clearance model: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
extendedclearance model1 CONSTRUCTExtended clearance modelPATILEA-VRANA ·

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Pharmacokinetics

clearance model adding uptake, efflux and passive diffusion across the hepatocyte membrane to metabolism, showing when transport rather than metabolism sets drug kinetics.

In pharmacokinetics, extended clearance model refers to clearance model adding uptake, efflux and passive diffusion across the hepatocyte membrane to metabolism, showing when transport rather than metabolism sets drug kinetics. This meaning comes from Patilea‐Vrana (2016) in Clinical Pharmacology & Therapeutics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

clearance1 fields · 2 citationsanchor · a standalone constructdiffusion6 fields · 12 citationsjingle · one name, six constructsmembrane4 fields · 4 citationsjingle · one word, four constructs

References

  1. Patilea‐Vrana, G., & Unadkat, J. (2016). Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model. Clinical Pharmacology & Therapeutics, 100(5), 413-418. https://doi.org/10.1002/cpt.437

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