Construct · 1 fields · 2 citations

clearance: a standalone construct

One name. One construct. A landmark on the map.

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clearance1 CONSTRUCTDrug clearancePANG · DRUG CLEARANCE

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Pharmacology and physiology

Rate the body clears a drug

In pharmacology, clearance is the volume of blood or plasma from which a substance is completely removed per unit of time, so it measures how fast the body eliminates a drug rather than how much of it is present. Pang and Rowland's 1977 analysis of hepatic clearance set out how blood flow, protein binding, and enzyme activity together fix the rate at which the liver strips a drug from the blood, and Cockcroft and Gault's 1976 formula estimated the kidney's creatinine clearance from a simple blood test. The referent is a rate of elimination inside a living body, scaled in millilitres per minute, and it has nothing to do with clearing a shipment through customs, granting a person access to secrets, or the gap left between two machine parts.[1][2]

Unit
The volume of blood or plasma fully cleared of a substance each minute, in millilitres per minute
Recovery means
Not applicable
Measured by
Calculated from dose and the area under the plasma concentration curve, or for the kidney from creatinine measured in serum and urine

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Nearby constructs

tolerance6 fields · 11 citationsjingle · one name, six constructstariff1 fields · 1 citationsanchor · a standalone constructdischarge3 fields · 3 citationsjingle · one word, three constructs

References

  1. Pang, K. S., & Rowland, M. (1977). Hepatic clearance of drugs. I. Theoretical considerations of a 'well-stirred' model and a 'parallel tube' model. Journal of Pharmacokinetics and Biopharmaceutics, 5(6), 625–653. https://doi.org/10.1007/BF01059688
  2. Cockcroft, D. W., & Gault, M. H. (1976). Prediction of creatinine clearance from serum creatinine. Nephron, 16(1), 31–41. https://doi.org/10.1159/000180580

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