Construct · 1 fields · 1 citations

free drug hypothesis: a standalone construct

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Pharmacokinetics

principle that only unbound drug crosses membranes and acts at the target, so efficacy tracks unbound rather than total concentration.

In pharmacokinetics, free drug hypothesis refers to principle that only unbound drug crosses membranes and acts at the target, so efficacy tracks unbound rather than total concentration. This meaning comes from Smith (2010) in Nature Reviews Drug Discovery.[1]

Unit
Recovery means
Measured by

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Nearby constructs

concentration4 fields · 4 citationsjingle · one word, four constructs efficacy4 fields · 4 citationsjingle · one word, four constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs

References

Smith, D. A., Di, L., & Kerns, E. H. (2010). The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nature Reviews Drug Discovery, 9(12), 929-939. https://doi.org/10.1038/nrd3287

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