Construct · 1 fields · 1 citations

genetic burden: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

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Synthetic biology

the growth and expression cost a host pays for carrying engineered constructs, which caps what a circuit can do.

In synthetic biology, genetic burden refers to the growth and expression cost a host pays for carrying engineered constructs, which caps what a circuit can do. This meaning comes from Ceroni (2015) in Nature Methods.[1]

Unit
Recovery means
Measured by

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Nearby constructs

burden3 fields · 6 citationsjingle · one word, three constructs circuit1 fields · 1 citationsanchor · a standalone construct cost4 fields · 4 citationsjingle · one word, four constructs

References

Ceroni, F., Algar, R., Stan, G., & Ellis, T. (2015). Quantifying cellular capacity identifies gene expression designs with reduced burden. Nature Methods, 12(5), 415-418. https://doi.org/10.1038/nmeth.3339

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