Construct · 1 fields · 1 citations

high-fidelity Cas9: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
high-fidelityCas91 CONSTRUCTHigh-fidelity Cas9KLEINSTIVER · GENOME EDITING

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Genome editing

Cas9 redesigned to weaken nonspecific DNA contacts so cutting at partly matching sites falls away.

In genome editing, high-fidelity Cas9 refers to cas9 redesigned to weaken nonspecific DNA contacts so cutting at partly matching sites falls away. This meaning comes from Kleinstiver (2016) in Nature.[1]

Unit
Recovery means
Measured by

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Nearby constructs

editing1 fields · 2 citationsanchor · a standalone constructmatching4 fields · 4 citationsjingle · one word, four constructs

References

  1. Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Zheng, Z., & Joung, J. K. (2016). High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects. Nature, 529(7587), 490-495. https://doi.org/10.1038/nature16526

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