Construct · 1 fields · 1 citations

HLA-B27 misfolding hypothesis: a standalone construct

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Rheumatology

the hypothesis that HLA-B27 heavy chains fold slowly and accumulate in the endoplasmic reticulum, causing a stress response that drives inflammation.

In rheumatology, HLA-B27 misfolding hypothesis refers to the hypothesis that HLA-B27 heavy chains fold slowly and accumulate in the endoplasmic reticulum, causing a stress response that drives inflammation. This meaning comes from Mear (1999) in The Journal of Immunology.[1]

Unit
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Nearby constructs

fold3 fields · 6 citationsjingle · one word, three constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs response4 fields · 4 citationsjingle · one word, four constructs

References

Mear, J. P., Schreiber, K. L., Münz, C., Zhu, X., Stevanović, S., Rammensee, H., Rowland-Jones, S. L., & Colbert, R. A. (1999). Misfolding of HLA-B27 as a Result of Its B Pocket Suggests a Novel Mechanism for Its Role in Susceptibility to Spondyloarthropathies. The Journal of Immunology, 163(12), 6665-6670. https://doi.org/10.4049/jimmunol.163.12.6665

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