Construct · 1 fields · 1 citations

horizontal pleiotropy: a standalone construct

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Genetic epidemiology

a variant affecting an outcome through paths other than the exposure under study, which biases causal estimates from genetic instruments.

In genetic epidemiology, horizontal pleiotropy refers to a variant affecting an outcome through paths other than the exposure under study, which biases causal estimates from genetic instruments. This meaning comes from Verbanck (2018) in Nature Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

MR-PRESSO1 fields · 1 citationsanchor · a standalone construct exposure6 fields · 13 citationsjingle · one name, six constructs pleiotropy1 fields · 3 citationsanchor · a standalone construct

References

Verbanck, M., Chen, C., Neale, B., & Do, R. (2018). Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nature Genetics, 50(5), 693-698. https://doi.org/10.1038/s41588-018-0099-7

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