Construct · 1 fields · 1 citations

ionizable lipid: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
ionizablelipid1 CONSTRUCTIonizable lipidSEMPLE · DRUG DELIVERY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Drug delivery

lipid that is neutral in blood but charged inside acidic endosomes, letting nucleic acid cargo escape into the cytoplasm.

In drug delivery, ionizable lipid refers to lipid that is neutral in blood but charged inside acidic endosomes, letting nucleic acid cargo escape into the cytoplasm. This meaning comes from Semple (2010) in Nature Biotechnology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

acid2 fields · 2 citationsjingle · one word, two carriersdelivery1 fields · 1 citationsanchor · a standalone constructescape2 fields · 2 citationsjingle · one word, two constructs

References

  1. Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., Hafez, I. M., Dorkin, J. R., Qin, J., Lam, K., Rajeev, K. G., Wong, K. F., Jeffs, L. B., Nechev, L., Eisenhardt, M. L., Jayaraman, M., Kazem, M., Maier, M. A., Srinivasulu, M., Weinstein, M. J., Chen, Q., Alvarez, R., Barros, S. A., De, S., Klimuk, S. K., Borland, T., Kosovrasti, V., Cantley, W. L., Tam, Y. K., Manoharan, M., Ciufolini, M. A., Tracy, M. A., de Fougerolles, A., MacLachlan, I., Cullis, P. R., Madden, T. D., & Hope, M. J. (2010). Rational design of cationic lipids for siRNA delivery. Nature Biotechnology, 28(2), 172-176. https://doi.org/10.1038/nbt.1602

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