Construct · 1 fields · 1 citations

kinase selectivity score: a standalone construct

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Medicinal chemistry

fraction of kinases in a panel that an inhibitor binds below a set affinity threshold, used to compare inhibitor selectivity.

In medicinal chemistry, kinase selectivity score refers to fraction of kinases in a panel that an inhibitor binds below a set affinity threshold, used to compare inhibitor selectivity. This meaning comes from Karaman (2008) in Nature Biotechnology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

affinity3 fields · 4 citationsjingle · one word, three constructs panel1 fields · 2 citationsanchor · a standalone construct score2 fields · 3 citationsjingle · one word, two constructs

References

Karaman, M. W., Herrgard, S., Treiber, D. K., Gallant, P., Atteridge, C. E., Campbell, B. T., Chan, K. W., Ciceri, P., Davis, M. I., Edeen, P. T., Faraoni, R., Floyd, M., Hunt, J. P., Lockhart, D. J., Milanov, Z. V., Morrison, M. J., Pallares, G., Patel, H. K., Pritchard, S., Wodicka, L. M., & Zarrinkar, P. P. (2008). A quantitative analysis of kinase inhibitor selectivity. Nature Biotechnology, 26(1), 127-132. https://doi.org/10.1038/nbt1358

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