Construct · 1 fields · 1 citations

Lilly MedChem rules: a standalone construct

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Medicinal chemistry

rule set assigning demerits to substructures likely to cause assay interference, reactivity or promiscuity, used to triage screening hits.

In medicinal chemistry, Lilly MedChem rules refers to rule set assigning demerits to substructures likely to cause assay interference, reactivity or promiscuity, used to triage screening hits. This meaning comes from Bruns (2012) in Journal of Medicinal Chemistry.[1]

Unit
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Nearby constructs

assay1 fields · 1 citationsanchor · a standalone construct cause3 fields · 7 citationsjingle · one word, three constructs interference4 fields · 5 citationsjingle · one word, four unrelated constructs

References

Bruns, R. F., & Watson, I. A. (2012). Rules for Identifying Potentially Reactive or Promiscuous Compounds. Journal of Medicinal Chemistry, 55(22), 9763-9772. https://doi.org/10.1021/jm301008n

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