Construct · 1 fields · 1 citations

lysosome-targeting chimera: a standalone construct

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Chemical biology

conjugate that binds an extracellular or membrane protein and a lysosome-shuttling receptor, routing the target to lysosomes for degradation.

In chemical biology, lysosome-targeting chimera refers to conjugate that binds an extracellular or membrane protein and a lysosome-shuttling receptor, routing the target to lysosomes for degradation. This meaning comes from Banik (2020) in Nature.[1]

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Nearby constructs

chimera2 fields · 4 citationsjingle · one word, two constructs degradation3 fields · 5 citationsjingle · one word, three constructs membrane4 fields · 4 citationsjingle · one word, four constructs

References

Banik, S. M., Pedram, K., Wisnovsky, S., Ahn, G., Riley, N. M., & Bertozzi, C. R. (2020). Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature, 584(7820), 291-297. https://doi.org/10.1038/s41586-020-2545-9

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