Construct · 1 fields · 1 citations

magic methyl effect: a standalone construct

One name. One construct. A landmark on the map.

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Medicinal chemistry

large gain in potency or other properties, sometimes over a hundredfold, from adding a single methyl group to a ligand.

In medicinal chemistry, magic methyl effect refers to large gain in potency or other properties, sometimes over a hundredfold, from adding a single methyl group to a ligand. This meaning comes from Schönherr (2013) in Angewandte Chemie International Edition.[1]

Unit
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Nearby constructs

gain4 fields · 4 citationsjingle · one word, four constructs group4 fields · 4 citationsjingle · one word, four constructs ligand2 fields · 2 citationsinvariant · one construct, two systems

References

Schönherr, H., & Cernak, T. (2013). Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions. Angewandte Chemie International Edition, 52(47), 12256-12267. https://doi.org/10.1002/anie.201303207

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