Construct · 2 fields · 2 citations

Where does potency collide?

One name. Different field. Different construct. One map.

● jingle · one word, two constructs Nearest construct by meaning·not indexed
potency2 CONSTRUCTSDevelopmental potencyALBERTS · CELL FATEDrug potencyGOODMAN & GILMAN · EC50

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2015Developmental potency2017Drug potency
2026

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Developmental biology

How many fates a cell can take

In developmental and stem-cell biology, potency is the range of cell types a cell can still give rise to: from a totipotent zygote that can form a whole organism, through pluripotent and multipotent progenitors, to a committed unipotent cell. Alberts and colleagues' Molecular biology of the cell describes how this capacity narrows as cells differentiate. The referent is a cell's developmental versatility, a count of accessible fates, and it has nothing to do with how strong a drug is beyond the shared root of latent power.[1]

Unit
The breadth of cell fates a cell can still produce (toti-, pluri-, multi-, unipotent)
Recovery means
Not applicable
Measured by
Assessed by differentiation assays, lineage tracing, and tests of whether a cell can contribute to multiple tissues or a whole organism

Pharmacology

How much drug a given effect needs

In pharmacology, potency is the amount of a drug needed to produce a given effect: a more potent drug reaches the same response at a lower concentration or dose, which fixes the position of its dose–response curve along the dose axis. Goodman and Gilman's therapeutics reference distinguishes potency from efficacy, the maximal effect a drug can produce. The referent is a dose-scaling property summarised by measures such as the EC50 or ED50, and it is a different construct from a cell's developmental versatility, joined to it only by the word.[2]

Unit
The concentration or dose producing a specified effect (e.g., EC50, ED50)
Recovery means
Not applicable
Measured by
Read from the dose–response curve as the EC50/ED50; the lower the value, the greater the potency

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Nearby collisions

efficacy4 fields · 4 citationsjingle · one word, four constructsact2 fields · 2 citationsjingle · one word, two constructsassay1 fields · 1 citationsanchor · a standalone construct

References

  1. Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2015). Molecular biology of the cell (6th ed.). Garland Science. ISBN 9780815344322
  2. Brunton, L. L., Hilal-Dandan, R., & Knollmann, B. C. (Eds.). (2017). Goodman & Gilman's the pharmacological basis of therapeutics (13th ed.). McGraw-Hill Education. ISBN 9781259584732

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