Construct · 3 fields · 3 citations

dose: one construct, many systems

One name. One construct. Different systems. One map.

● invariant · one construct, three systems Nearest construct by meaning·not indexed
the agent that harms and the agent that heals are measured the same wayfrom a quantity of chemical to a quantity of radiant energydose3 SYSTEMSAbsorbed doseATTIX · GRAYToxic doseKLAASSEN · DOSE-RESPONSEDrug doseGOODMAN & GILMAN · REGIMEN

Spokes are the systems the one construct recurs in; dashed arcs are shared lineage. Tap a field for its definition, unit, and measures.

1986Absorbed dose2013Toxic dose2017Drug dose
2026

Drag to watch the word get claimed. Each field appears at the publication date of the earliest source cited for it. Tap a year to see which.

Radiation physics

Energy deposited per unit mass

In radiological physics, the absorbed dose is the energy deposited by ionising radiation per unit mass of tissue or material, measured in grays. Attix's Introduction to radiological physics and radiation dosimetry develops how this quantity is defined and measured. The referent is the amount of an agent, here radiant energy, delivered to a system per unit of exposure, the same delivered-quantity construct that pharmacology applies to drugs and toxicology to poisons.[1]

Unit
Energy absorbed per unit mass (gray, J/kg)
Recovery means
Not applicable
Measured by
Measured with ionisation chambers, dosimeters, or calorimetry, and modelled from source, geometry, and tissue properties

Toxicology

the quantity of a substance an organism is exposed to, which determines whether it is harmless or toxic.

In toxicology, the dose is the quantity of a substance to which an organism is exposed, and the central principle is that the dose determines whether a substance is harmless or toxic (the dose–response relationship). Casarett and Doull's toxicology reference treats this relationship and measures such as the LD50. The referent is the amount of an agent received by a system, the quantity on which effect depends, which is the same construct whether the agent is a poison, a therapeutic drug, or ionising radiation.[2]

Unit
The quantity of substance received per exposure, often per unit body weight
Recovery means
Not applicable
Measured by
Related to effect through dose–response curves and summary points such as the LD50 or NOAEL

Pharmacology

The amount of drug administered

In pharmacology, the dose is the amount of a drug given on a single administration or over a defined interval, chosen to achieve a therapeutic effect while limiting harm. Goodman and Gilman's therapeutics reference treats dose selection, dose–response, and the dosing regimen. The referent is the quantity of agent delivered to the body, the same delivered-amount construct that toxicology measures for poisons and radiation physics measures as absorbed energy, one idea recurring across the three systems.[3]

Unit
The amount of drug administered per dose or per interval
Recovery means
Not applicable
Measured by
Set from the dose–response relationship and pharmacokinetics to reach a target exposure or effect

Next

Run it through the Collider, or take the citations with you.

See how dose sits against neighbouring constructs in the Collider, or export every reference on this page in one click.

Open in ColliderExport BibTeXReport this entry

Nearby constructs

exposure6 fields · 13 citationsjingle · one name, six constructsradiation3 fields · 3 citationsjingle · one word, three physical and biological constructsadherence3 fields · 5 citationsjingle · one word, three constructs

References

  1. Attix, F. H. (1986). Introduction to radiological physics and radiation dosimetry. John Wiley & Sons. ISBN 9780471011460
  2. Klaassen, C. D. (Ed.). (2013). Casarett and Doull's toxicology: The basic science of poisons (8th ed.). McGraw-Hill Education. ISBN 9780071769235
  3. Brunton, L. L., Hilal-Dandan, R., & Knollmann, B. C. (Eds.). (2017). Goodman & Gilman's the pharmacological basis of therapeutics (13th ed.). McGraw-Hill Education. ISBN 9781259584732

Cited on this page?

Confirm your construct, or correct us.

If your work is cited behind one of these entries, you know better than we do whether we captured the meaning right. Confirm it, suggest an edit, or dispute it, and your name goes on the entry as an author who has checked it, linked to your ORCID.

Claim your construct