Construct · 1 fields · 1 citations

mechanism-based inactivation: a standalone construct

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Pharmacokinetics

irreversible enzyme inactivation in which the enzyme converts a drug into a reactive species that destroys it, linked to drug interactions and toxicity.

In pharmacokinetics, mechanism-based inactivation refers to irreversible enzyme inactivation in which the enzyme converts a drug into a reactive species that destroys it, linked to drug interactions and toxicity. This meaning comes from Amit S. Kalgutkar (2007) in Current Drug Metabolism.[1]

Unit
Recovery means
Measured by

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Nearby constructs

current3 fields · 6 citationsjingle · one word, three constructs metabolism3 fields · 3 citationsjingle · one word, three constructs species4 fields · 8 citationsjingle · one word, four constructs

References

Amit S. Kalgutkar, R. Scott Obach, & Tristan S. Maurer (2007). Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Chemical Mechanisms, Structure-Activity Relationships and Relationship to Clinical Drug-Drug Interactions and Idiosyncratic Adverse Drug Reactions. Current Drug Metabolism, 8(5), 407-447. https://doi.org/10.2174/138920007780866807

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