Construct · 1 fields · 1 citations

missing self hypothesis: a standalone construct

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Immunology

the idea that natural killer cells attack cells that have lost normal self MHC class I expression rather than cells that display something foreign.

In immunology, missing self hypothesis refers to the idea that natural killer cells attack cells that have lost normal self MHC class I expression rather than cells that display something foreign. This meaning comes from Kärre (1986) in Nature.[1]

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Nearby constructs

attack4 fields · 10 citationsjingle · one word, four constructs class3 fields · 3 citationsjingle · one word, three constructs display2 fields · 3 citationsjingle · one word, two constructs

References

Kärre, K., Ljunggren, H. G., Piontek, G., & Kiessling, R. (1986). Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy. Nature, 319(6055), 675-678. https://doi.org/10.1038/319675a0

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