Construct · 1 fields · 1 citations

mitochondrial-lysosomal axis theory of aging: a standalone construct

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Biology of aging

the theory that imperfect autophagy lets damaged mitochondria and lipofuscin build up in long-lived cells, driving aging.

In biology of aging, mitochondrial-lysosomal axis theory of aging refers to the theory that imperfect autophagy lets damaged mitochondria and lipofuscin build up in long-lived cells, driving aging. This meaning comes from Brunk (2002) in European Journal of Biochemistry.[1]

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Nearby constructs

aging4 fields · 5 citationsjingle · one word, four constructs autophagy1 fields · 3 citationsanchor · a standalone construct axis1 fields · 1 citationsanchor · a standalone construct

References

Brunk, U. T., & Terman, A. (2002). The mitochondrial‐lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. European Journal of Biochemistry, 269(8), 1996-2002. https://doi.org/10.1046/j.1432-1033.2002.02869.x

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