Construct · 1 fields · 1 citations

modified nucleoside mRNA: a standalone construct

One name. One construct. A landmark on the map.

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RNA therapeutics

replacing standard bases in a messenger with modified ones so innate immune receptors do not flag it as foreign.

In rna therapeutics, modified nucleoside mRNA refers to replacing standard bases in a messenger with modified ones so innate immune receptors do not flag it as foreign. This meaning comes from Karikó (2005) in Immunity.[1]

Unit
Recovery means
Measured by

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Nearby constructs

immunity3 fields · 5 citationsjingle · one word, three constructs

References

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005). Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA. Immunity, 23(2), 165-175. https://doi.org/10.1016/j.immuni.2005.06.008

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