Construct · 3 fields · 5 citations

Where does immunity collide?

One name. Different field. Different construct. One map.

● jingle · one word, three constructs Nearest construct by meaningresponsecompare the meanings
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Every construct on the map is compared with every other by the meaning of its definitions, and the closest one is surfaced here. The nearest construct to immunity is response.

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immunity3 CONSTRUCTSImmunologyMEDZHITOV · INNATEEpidemiologyFINE · THRESHOLDLawHARLOW V. FITZGERALD

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2026

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Immunology

Biological defence against pathogens

The body's protection against infection, carried by two systems that Medzhitov and Janeway set side by side in their 2000 account Innate Immunity: an innate arm that recognises conserved microbial patterns within minutes and responds the same way each time, and an adaptive arm that learns a specific pathogen over days and remembers it. The referent is a single organism defending itself, and the unit is the cell and molecule, so a claim about immunity here is a claim about a physiological mechanism that can be assayed in one host. It shares only the metaphor of protection with the other meanings; nothing about antibodies transfers to a population, a court, or an argument.[1]

Unit
One organism's cellular and molecular defence against a pathogen
Recovery means
Clearance of the pathogen and, for the adaptive arm, lasting memory against re-infection
Measured by
Assays of antibody titre, lymphocyte response, and pathogen clearance in a host

Epidemiology

Population resistance above a threshold

A property not of any body but of a population: the resistance a group shows to the spread of an agent because a sufficient fraction of it is already immune. Fine's 1993 review Herd Immunity: History, Theory, Practice traces the idea to a threshold, the level of immune individuals above which each case produces fewer than one further case and an epidemic cannot sustain itself. Anderson and May had earlier tied that level to the basic reproduction number, giving the critical proportion as one minus its reciprocal. The referent is the group and the unit is the fraction immune, so herd immunity can hold while many individuals remain fully susceptible, which is exactly what separates it from the immunological meaning.[2][3]

Unit
The fraction of a population immune, relative to a transmission threshold
Recovery means
Not applicable
Measured by
The critical immune proportion derived from the basic reproduction number and observed coverage

Law

Protection from liability or suit

A shield the law grants a person or body against being sued or prosecuted, having nothing to do with resisting anything and everything to do with who may be held to answer. In Harlow v. Fitzgerald (1982) the Supreme Court recast qualified immunity for government officials as an objective test: officials are protected unless their conduct violated clearly established rights a reasonable person would have known, so a suit can be dismissed before trial regardless of the official's actual intent. Baude's 2018 argument that the doctrine lacks a legal foundation shows how contested the construct is. The referent is a legal relation between a defendant and a claim, and the unit is the availability of the action itself, which no assay or coverage rate could measure.[4][5]

Unit
A defendant's protection from a legal action or prosecution
Recovery means
Not applicable
Measured by
Judicial rulings on whether a claim is barred, tested against the clearly-established-law standard

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Nearby collisions

resilience6 fields · 9 citationsjingle · one name, six constructsthreat6 fields · 14 citationsjingle · one name, six constructsvulnerability6 fields · 15 citationsjingle · one name, six constructsinoculation1 fields · 2 citationsanchor · a standalone constructherd immunity1 fields · 3 citationsanchor · a standalone construct

References

  1. Medzhitov, R., & Janeway, C., Jr. (2000). Innate immunity. New England Journal of Medicine, 343(5), 338–344. https://doi.org/10.1056/NEJM200008033430506
  2. Fine, P. E. M. (1993). Herd immunity: History, theory, practice. Epidemiologic Reviews, 15(2), 265–302. https://doi.org/10.1093/oxfordjournals.epirev.a036121
  3. Anderson, R. M., & May, R. M. (1985). Vaccination and herd immunity to infectious diseases. Nature, 318(6044), 323–329. https://doi.org/10.1038/318323a0
  4. Harlow v. Fitzgerald, 457 U.S. 800 (1982).
  5. Baude, W. (2018). Is qualified immunity unlawful? California Law Review, 106(1), 45–90.

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