Construct · 1 fields · 1 citations

molecular chameleonicity: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
molecularchameleonicity1 CONSTRUCTMolecular chameleonicityWHITTY · DRUG DISCOVERY

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Drug discovery

ability of a large molecule to change conformation and expose or hide polar groups depending on its environment, allowing permeability beyond usual property limits.

In drug discovery, molecular chameleonicity refers to ability of a large molecule to change conformation and expose or hide polar groups depending on its environment, allowing permeability beyond usual property limits. This meaning comes from Whitty (2016) in Drug Discovery Today.[1]

Unit
Recovery means
Measured by

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Nearby constructs

conformation2 fields · 2 citationsjingle · one word, two constructsenvironment1 fields · 2 citationsanchor · a standalone constructpermeability5 fields · 6 citationsjingle · one word, five constructs

References

  1. Whitty, A., Zhong, M., Viarengo, L., Beglov, D., Hall, D. R., & Vajda, S. (2016). Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs. Drug Discovery Today, 21(5), 712-717. https://doi.org/10.1016/j.drudis.2016.02.005

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