Construct · 1 fields · 1 citations

molecular obesity: a standalone construct

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Medicinal chemistry

tendency of drug discovery programs to raise potency by adding size and lipophilicity, which degrades compound quality and raises attrition.

In medicinal chemistry, molecular obesity refers to tendency of drug discovery programs to raise potency by adding size and lipophilicity, which degrades compound quality and raises attrition. This meaning comes from Hann (2011) in MedChemComm.[1]

Unit
Recovery means
Measured by

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Nearby constructs

attrition2 fields · 2 citationsjingle · one word, two constructs compound3 fields · 3 citationsjingle · one word, three constructs potency2 fields · 2 citationsjingle · one word, two constructs

References

Hann, M. M. (2011). Molecular obesity, potency and other addictions in drug discovery. MedChemComm, 2(5), 349-355. https://doi.org/10.1039/c1md00017a

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