Construct · 1 fields · 1 citations

oncogene-induced DNA damage model: a standalone construct

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Cancer biology

the model that activated oncogenes cause replication stress and DNA damage early in tumors, selecting for loss of p53 and other checkpoints.

In cancer biology, oncogene-induced DNA damage model refers to the model that activated oncogenes cause replication stress and DNA damage early in tumors, selecting for loss of p53 and other checkpoints. This meaning comes from Halazonetis (2008) in Science.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cause3 fields · 7 citationsjingle · one word, three constructs damage(s)4 fields · 4 citationsjingle · one word, four constructs loss2 fields · 3 citationsjingle · one word, two constructs

References

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008). An Oncogene-Induced DNA Damage Model for Cancer Development. Science, 319(5868), 1352-1355. https://doi.org/10.1126/science.1140735

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