Construct · 1 fields · 1 citations

rack: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
rack1 CONSTRUCTRACK1RON · RACK1

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Cell biology

A scaffold protein that anchors activated protein kinase C

In cell biology, RACK (receptor for activated C-kinase) names a class of scaffold proteins (the best known is RACK1) that bind and anchor activated protein kinase C, positioning the enzyme near its substrates and shaping signal transduction; the name is an acronym that happens to spell the English word. Ron and colleagues cloned RACK1 and showed it is a homolog of the beta subunit of G proteins. The referent is a signalling-scaffold protein identified by its binding partners, colliding with wine racking and gear racks purely through the acronym.[1]

Unit
The anchoring of activated protein kinase C by a scaffold protein
Recovery means
Not applicable
Measured by
Characterised by binding assays of RACK1 with activated PKC and effects on downstream signalling

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Nearby constructs

barrel1 fields · 1 citationsanchor · a standalone constructbasis3 fields · 5 citationsjingle · one word, three constructsbeta3 fields · 3 citationsjingle · one word, three constructs

References

  1. Ron, D., Chen, C.-H., Caldwell, J., Jamieson, L., Orr, E., & Mochly-Rosen, D. (1994). Cloning of an intracellular receptor for protein kinase C: A homolog of the beta subunit of G proteins. Proceedings of the National Academy of Sciences, 91(3), 839–843. https://doi.org/10.1073/pnas.91.3.839

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