Construct · 1 fields · 1 citations

reactive metabolite: a standalone construct

One name. One construct. A landmark on the map.

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reactivemetabolite1 CONSTRUCTReactive metabolitePARK · TOXICOLOGY

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Toxicology

a metabolite formed in the body that reacts with cellular macromolecules and is implicated in drug toxicity.

In toxicology, reactive metabolite refers to a metabolite formed in the body that reacts with cellular macromolecules and is implicated in drug toxicity. This meaning comes from Park (2011) in Nature Reviews Drug Discovery.[1]

Unit
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Measured by

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Nearby constructs

body2 fields · 3 citationsjingle · one word, two constructs

References

  1. Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., Lambert, C., Laverty, H. G., Naisbitt, D. J., Nelson, S., Nicoll-Griffith, D. A., Obach, R. S., Routledge, P., Smith, D. A., Tweedie, D. J., Vermeulen, N., Williams, D. P., Wilson, I. D., & Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. Nature Reviews Drug Discovery, 10(4), 292-306. https://doi.org/10.1038/nrd3408

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