Construct · 1 fields · 1 citations

scaffold hopping: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Drug discovery

search for compounds with a different core structure that keep the activity of a known ligand.

In drug discovery, scaffold hopping refers to search for compounds with a different core structure that keep the activity of a known ligand. This meaning comes from Böhm (2004) in Drug Discovery Today: Technologies.[1]

Unit
Recovery means
Measured by

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Nearby constructs

ligand2 fields · 2 citationsinvariant · one construct, two systems scaffolding4 fields · 6 citationsjingle · one word, four referents search4 fields · 7 citationsjingle · one word, four constructs

References

Böhm, H., Flohr, A., & Stahl, M. (2004). Scaffold hopping. Drug Discovery Today: Technologies, 1(3), 217-224. https://doi.org/10.1016/j.ddtec.2004.10.009

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