Construct · 1 fields · 1 citations

scaffold prozone effect: a standalone construct

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Cell signalling

the fall in signalling when a scaffold is too abundant and binds partners on separate molecules.

In cell signalling, scaffold prozone effect refers to the fall in signalling when a scaffold is too abundant and binds partners on separate molecules. This meaning comes from Levchenko (2000) in Proceedings of the National Academy of Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs fall2 fields · 3 citationsjingle · one word, two constructs high-dose hook effect1 fields · 1 citationsanchor · a standalone construct

References

Levchenko, A., Bruck, J., & Sternberg, P. W. (2000). Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proceedings of the National Academy of Sciences, 97(11), 5818-5823. https://doi.org/10.1073/pnas.97.11.5818

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