Construct · 1 fields · 1 citations

self-amplifying RNA: a standalone construct

One name. One construct. A landmark on the map.

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RNA therapeutics

messenger carrying a replicase so it copies itself in the cell, giving more protein from a smaller dose.

In rna therapeutics, self-amplifying RNA refers to messenger carrying a replicase so it copies itself in the cell, giving more protein from a smaller dose. This meaning comes from Geall (2012) in Proceedings of the National Academy of Sciences.[1]

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs dose3 fields · 3 citationsinvariant · one construct, three systems

References

Geall, A. J., Verma, A., Otten, G. R., Shaw, C. A., Hekele, A., Banerjee, K., Cu, Y., Beard, C. W., Brito, L. A., Krucker, T., O’Hagan, D. T., Singh, M., Mason, P. W., Valiante, N. M., Dormitzer, P. R., Barnett, S. W., Rappuoli, R., Ulmer, J. B., & Mandl, C. W. (2012). Nonviral delivery of self-amplifying RNA vaccines. Proceedings of the National Academy of Sciences, 109(36), 14604-14609. https://doi.org/10.1073/pnas.1209367109

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