Construct · 1 fields · 1 citations

self-inactivating vector: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
self-inactivatingvector1 CONSTRUCTSelf-inactivating vectorZUFFEREY · GENE THERAPY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Gene therapy

vector whose long terminal repeat is crippled on integration, lowering the chance of activating nearby host genes.

In gene therapy, self-inactivating vector refers to vector whose long terminal repeat is crippled on integration, lowering the chance of activating nearby host genes. This meaning comes from Zufferey (1998) in Journal of Virology.[1]

Unit
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Measured by

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Nearby constructs

chance4 fields · 6 citationsjingle · one word, four constructshost2 fields · 2 citationsjingle · one word, two constructsintegration5 fields · 7 citationsjingle · one word, five constructs

References

  1. Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998). Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery. Journal of Virology, 72(12), 9873-9880. https://doi.org/10.1128/jvi.72.12.9873-9880.1998

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