Construct · 1 fields · 1 citations

shet: a standalone construct

One name. One construct. A landmark on the map.

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Medical genetics

an estimate of the fitness cost of carrying one loss-of-function copy of a gene, inferred from the frequency of protein-truncating variants.

In medical genetics, shet refers to an estimate of the fitness cost of carrying one loss-of-function copy of a gene, inferred from the frequency of protein-truncating variants. This meaning comes from Cassa (2017) in Nature Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cost4 fields · 4 citationsjingle · one word, four constructs fitness4 fields · 5 citationsjingle · one word, four constructs frequency4 fields · 7 citationsjingle · one word, four constructs

References

Cassa, C. A., Weghorn, D., Balick, D. J., Jordan, D. M., Nusinow, D., Samocha, K. E., O'Donnell-Luria, A., MacArthur, D. G., Daly, M. J., Beier, D. R., & Sunyaev, S. R. (2017). Estimating the selective effects of heterozygous protein-truncating variants from human exome data. Nature Genetics, 49(5), 806-810. https://doi.org/10.1038/ng.3831

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