Construct · 1 fields · 2 citations

sickling: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
sickling1 CONSTRUCTSickling (cells)HERRICK · 1910

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Hematology

Red cells deform into a rigid crescent

In hematology, sickling is the process by which red blood cells deform from their normal flexible disc into a rigid, elongated crescent or sickle shape. In sickle cell disease it occurs when abnormal haemoglobin S polymerises under low oxygen, distorting the cell; the stiffened cells obstruct small vessels and are destroyed early, causing pain crises and anaemia. Herrick's 1910 case report first described the sickle-shaped cells, and Pauling and colleagues' Sickle cell anemia, a molecular disease traced the defect to the haemoglobin molecule. The referent is a pathological cell deformation, unrelated to a dancer's foot beyond the crescent shape both are named for.[1][2]

Unit
The fraction of red cells assuming the sickle shape under deoxygenation
Recovery means
Early sickling reverses on re-oxygenation, but repeated cycles leave cells permanently deformed
Measured by
Observed on blood film and by sickle-solubility and deoxygenation tests, with haemoglobin electrophoresis for haemoglobin S

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Nearby constructs

alignment6 fields · 12 citationsjingle · one name, six constructsbend1 fields · 1 citationsanchor · a standalone constructcase2 fields · 3 citationsjingle · one word, two constructs

References

  1. Herrick, J. B. (1910). Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Archives of Internal Medicine, 6(5), 517–521. https://doi.org/10.1001/archinte.1910.00050330050003
  2. Pauling, L., Itano, H. A., Singer, S. J., & Wells, I. C. (1949). Sickle cell anemia, a molecular disease. Science, 110(2865), 543–548. https://doi.org/10.1126/science.110.2865.543

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