Construct · 2 fields · 2 citations

Where does silver stain collide?

One name. Different field. Different construct. One map.

● jingle · one word, two constructs Nearest construct by meaning·not indexed
silverstain2 CONSTRUCTSSilver stain (tissue)BROWN · ARGYROPHILSilver stain (gel)SWITZER · GEL PROTEINS

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1956Silver stain (tissue)1979Silver stain (gel)
2026

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Histology

a histology method that deposits metallic silver on structures such as nerve fibres so they stand out dark.

In histology a silver stain is a method that deposits metallic silver on particular tissue structures (nerve fibres, reticular fibres, neurofibrils) so that otherwise invisible elements stand out dark under the microscope. Brown and Vogelaar's 1956 Amino-silver staining of nervous tissue is one of many protocols in which silver ions are reduced selectively onto argyrophilic structures. Here the term names a contrast technique for microscopy whose goal, revealing anatomy, has nothing to do with colouring a window. The referent is a selective silver deposit on tissue.[1]

Unit
The selective darkening of silver-affine tissue structures
Recovery means
Not applicable
Measured by
Assessed by the contrast and selectivity of silver deposition on the target structures

Protein biochemistry

a highly sensitive method that detects proteins in a polyacrylamide gel by reducing bound silver ions to metallic silver.

In protein biochemistry a silver stain is a highly sensitive way to detect proteins and peptides separated in a polyacrylamide gel: silver ions bind the protein bands and are reduced to visible metallic silver, revealing far less material than dye stains can. Switzer, Merril, and Shifrin's 1979 A highly sensitive silver stain established the approach as a standard of the electrophoresis bench. The referent is a band-detection technique measured by its sensitivity, again sharing only the name with the glass colorant and the tissue stain. The common thread across all three is silver reduced to produce contrast, put to three unrelated ends.[2]

Unit
The least protein per band the stain can render visible
Recovery means
Not applicable
Measured by
Characterised by detection sensitivity (nanograms of protein per band) and by background staining

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compound3 fields · 3 citationsjingle · one word, three constructscontrast4 fields · 4 citationsjingle · one word, four constructs

References

  1. Brown, J. O., & Vogelaar, J. P. M. (1956). Amino-silver staining of nervous tissue. Stain Technology, 31(4), 159–165. https://doi.org/10.3109/10520295609113797
  2. Switzer, R. C., Merril, C. R., & Shifrin, S. (1979). A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels. Analytical Biochemistry, 98(1), 231–237. https://doi.org/10.1016/0003-2697(79)90732-2

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