Construct · 1 fields · 1 citations

Simon's two-stage design: a standalone construct

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Clinical trials

a phase II single-arm design that stops early for futility after a first stage if too few responses occur, minimizing expected sample size.

In clinical trials, Simon's two-stage design refers to a phase II single-arm design that stops early for futility after a first stage if too few responses occur, minimizing expected sample size. This meaning comes from Simon (1989) in Controlled Clinical Trials.[1]

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phase5 fields · 6 citationsjingle · one word, five constructs sample3 fields · 3 citationsjingle · one word, three constructs size1 fields · 1 citationsanchor · a standalone construct

References

Simon, R. (1989). Optimal two-stage designs for phase II clinical trials. Controlled Clinical Trials, 10(1), 1-10. https://doi.org/10.1016/0197-2456(89)90015-9

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