Construct · 1 fields · 1 citations

somatic hypermutation: a standalone construct

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Immunology

targeted introduction of point mutations into antibody genes in activated B cells, generating variants for selection.

In immunology, somatic hypermutation refers to targeted introduction of point mutations into antibody genes in activated B cells, generating variants for selection. This meaning comes from Muramatsu (2000) in Cell.[1]

Unit
Recovery means
Measured by

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Nearby constructs

class switch recombination1 fields · 1 citationsanchor · a standalone construct cell2 fields · 3 citationsjingle · one word, two constructs selection4 fields · 5 citationsjingle · one word, four constructs

References

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000). Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell, 102(5), 553-563. https://doi.org/10.1016/s0092-8674(00)00078-7

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