Construct · 1 fields · 2 citations

splicing: a standalone construct

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splicing1 CONSTRUCTRNA splicingBERGET & SHARP · mRNA

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Molecular biology

Removing introns and joining exons in RNA

In molecular biology, splicing is the step in which a cell removes the non-coding stretches (introns) from a freshly copied RNA transcript and joins the remaining coding stretches (exons) into the finished messenger RNA. Berget, Moore, and Sharp reported this in 1977, when they found that an adenovirus messenger RNA was assembled from segments that lie apart on the DNA, and Walter Gilbert's 1978 note Why genes in pieces? gave the discarded and retained pieces the names introns and exons. Here the referent is an enzyme-driven edit of a molecule inside the cell, not a woven rope join or a join between two shots of film.[1][2]

Unit
One intron removed and its flanking exons joined within a single transcript
Recovery means
Not applicable
Measured by
Detected by comparing an RNA to its gene and by sequencing the mature transcript to see which segments were kept and which were removed

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Nearby constructs

cut2 fields · 2 citationsjingle · one word, two constructsediting1 fields · 2 citationsanchor · a standalone constructintron1 fields · 1 citationsanchor · a single construct

References

  1. Berget, S. M., Moore, C., & Sharp, P. A. (1977). Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proceedings of the National Academy of Sciences, 74(8), 3171–3175. https://doi.org/10.1073/pnas.74.8.3171
  2. Gilbert, W. (1978). Why genes in pieces? Nature, 271(5645), 501. https://doi.org/10.1038/271501a0

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